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Documentation for Histone footprinting

Open SaideepGona opened this issue 5 years ago • 3 comments

Hello. I have histone data in addition to ATACseq, and I was interested in running the footprinting analysis on the histone data as well as on the classical ATACseq. Unfortunately it doesn't seem to be documented in the papers exactly what algorithm is being used and how it should be interpreted. Some feedback would be appreciated!

SaideepGona avatar Jul 12 '20 14:07 SaideepGona

In addition, I can't seem to find much on how the differential atacseq profiles are calculated and reported

SaideepGona avatar Jul 12 '20 15:07 SaideepGona

Dear Saideep,

Indee, we currently have no examples based on histone data, but the tool documentation page, should contain all necessary information.

https://www.regulatory-genomics.org/hint/tool-usage/

The overall usage of the tools are analogous to the atac-seq example.

best, Ivan

Em dom., 12 de jul. de 2020 às 16:31, Saideep Gona [email protected] escreveu:

Hello. I have histone data in addition to ATACseq, and I was interested in running the footprinting analysis on the histone data as well as on the classical ATACseq. Unfortunately it doesn't seem to be documented in the papers exactly what algorithm is being used and how it should be interpreted. Some feedback would be appreciated!

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igcf avatar Jul 13 '20 07:07 igcf

But is there any specific explanation of how the histone footprinting algorithm differs from that of the ATACseq one? It's hard to use the outputs without confidently understanding this.

SaideepGona avatar Jul 13 '20 12:07 SaideepGona